Ca 2+ /Calmodulin Kinase II-Dependent Phosphorylation of Ryanodine Receptors Suppresses Ca 2+ Sparks and Ca 2+ Waves in Cardiac Myocytes
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Ca /Calmodulin Kinase II–Dependent Phosphorylation of Ryanodine Receptors Suppresses Ca Sparks and Ca Waves in Cardiac Myocytes
The multifunctional Ca /calmodulin-dependent protein kinase II C (CaMKII C) is found in the macromolecular complex of type 2 ryanodine receptor (RyR2) Ca release channels in the heart. However, the functional role of CaMKII-dependent phosphorylation of RyR2 is highly controversial. To address this issue, we expressed wild-type, constitutively active, or dominant-negative CaMKII C via adenoviral...
متن کاملCa2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes.
The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta(C) (CaMKIIdelta(C)) is found in the macromolecular complex of type 2 ryanodine receptor (RyR2) Ca(2+) release channels in the heart. However, the functional role of CaMKII-dependent phosphorylation of RyR2 is highly controversial. To address this issue, we expressed wild-type, constitutively active, or dominant-negative CaM...
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Previous studies in transgenic mice and with isolated ryanodine receptors (RyR) have indicated that Ca -calmodulin-dependent protein kinase II (CaMKII) can phosphorylate RyR and activate local diastolic sarcoplasmic reticulum (SR) Ca release events (Ca sparks) and RyR channel opening. Here we use relatively controlled physiological conditions in saponin-permeabilized wild type (WT) and phosphol...
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A rise in intracellular Ca (Ca i) mediates various cellular functions ranging from fertilization to gene expression. A ubiquitous Ca influx pathway that contributes significantly to the generation of Ca i signals, especially in non-excitable cells, is store-operated Ca entry (SOCE). Consequently, the modulation of SOCE current affects Ca i dynamics and thus the ensuing cellular response. Theref...
متن کاملAdrenergic stimulation of rat resistance arteries affects Ca(2+) sparks, Ca(2+) waves, and Ca(2+) oscillations.
Confocal laser scanning microscopy and fluo 4 were used to visualize local and whole cell Ca(2+) transients within individual smooth muscle cells (SMC) of intact, pressurized rat mesenteric small arteries during activation of alpha1-adrenoceptors. A method was developed to record the Ca(2+) transients within individual SMC during the changes in arterial diameter. Three distinct types of "Ca(2+)...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000258022.13090.55